Große trophischen Geschwüren

Große trophischen Geschwüren

Große trophischen Geschwüren Krampfadern und trophischen Geschwüren Foto Große trophischen Geschwüren


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Große trophischen Geschwüren Von Varizen Blutegel

Vermittler von "hedgehog" übermittelnden bahnen, dazugehörige zusammenetzungen und verwendungen Broker "hedgehog" pave the sending, große trophischen Geschwüren, associated together menet tions and uses translated from German DE T2. Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Hemmung der Aktivierung eines Hedgehog-Wegs in einer Zelle, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel I große trophischen Geschwüren, ist: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell, wherein the Behandlung von Thrombophlebitis troksevazin is an organic molecule represented by the general formula I is: Verfahren zur Hemmung der Aktivierung einer Hedgehog-Weg in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um eine Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel Iist: A method of inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in an amount sufficient to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula I is: Use of a compound for preparing a medicament wie man Krampfadern an den Beinen zu heilen inhibiting activation of a hedgehog pathway in a cell, wherein the compound is an organic molecule represented by the general formula III is: Verfahren zur Hemmung der Aktivierung einer Hedgehog-Weg in einer Zelle, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um die Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IIIist: A method of inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in a sufficient amount to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula III is: Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell, wherein the compound is an organic molecule represented by the general formula IV is: Verfahren zur Hemmung der Aktivierung einer Hedgehog-Weg in einer Zelle, große trophischen Geschwüren, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um die Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IVgroße trophischen Geschwüren, ist: A method große trophischen Geschwüren inhibiting activation of a hedgehog pathway in a cell comprising contacting the cell in vitro with a compound in a sufficient amount to inhibit hedgehog signaling, wherein the compound is an organic molecule represented by the general formula IV is: A method or use according to any one of claims 1 to 4, wherein Y and Z represent O, respectively.

A method or use according to claim 1 or 2, wherein E is NR 8. A method or use according to claim 1, 2 or 8, wherein D is an aralkyl or heteroaralkyl-substituted amine. A method or use according to claim 3, 4, große trophischen Geschwüren, 5 or 6, wherein M is absent. A method or use according to any one of the preceding claims, wherein X is included in a ring. A method or use according to any one of the preceding claims, wherein X is included in a diazacarbocycle.

A method or use according to any preceding claim, große trophischen Geschwüren, wherein XLR 4 includes a cyclic amine. A method or use according to any one of the preceding claims, große trophischen Geschwüren, wherein at least one of the radicals R 1, R 2 and R 3 includes an aryl group.

A method or use according to any one of the preceding claims, wherein R 1 represents a branched große trophischen Geschwüren, cycloalkyl or cycloalkylalkyl. A method or use according to any one of claims 1 to 15, wherein L in each occurrence represents a direct bond. Use of a compound for preparing a medicament for inhibiting activation of a hedgehog pathway in a cell, große trophischen Geschwüren, wherein the compound is an organic molecule represented by the general formula VI is: Verfahren zur Hemmung der Aktivierung einer Hedgehog-Weg in einer Große trophischen Geschwüren, umfassend das Inkontaktbringen der Zelle in vitro mit einer Verbindung in einer ausreichenden Menge, um die Hedgehog-Signalgebung zu inhibieren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel VIist: A method of inhibiting activation of a hedgehog pathway in a cell comprising, in order to inhibit contacting the cell in vitro with a compound in a sufficient amount of the hedgehog signaling, wherein the compound is an organic molecule represented by the general formula VI is: A method or use according to claim 18 or 19, wherein at least one occurrence of J is part of a heterocyclic ring having 5 to 8 members is.

A method or use according to claim 18 or 19, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine. The method or use of claim 21, wherein the cyclic diamine is a substituted or unsubstituted piperazine.

A method or use according to claim 22, große trophischen Geschwüren, wherein the cyclic diamine with one or more groups große trophischen Geschwüren from oxo, C alkyl and C alkyl substituted. A method or use according to claim 18 or 19, wherein NJ 2, taken together, form a substituted or unsubstituted heterocyclic ring to which the other occurrence of N is attached, represents.

A method or use according to claim 18 or 19, wherein Große trophischen Geschwüren 9, taken together, form a substituted or unsubstituted heterocyclic ring to which the other occurrence of N is attached, represents. Substituted method or use of any große trophischen Geschwüren of claims 18 to 25, wherein one or both occurrences of J with one or more groups selected from C alkyl, C alkyl, C -Alkylthioether, amido, and oxo are.

A method or use according to any one of claims 18 to 26, große trophischen Geschwüren, wherein R 5 represents a branched alkyl, cycloalkyl, or cycloalkylalkyl. Moskau Laserbehandlung von Varizen method or use according to any one of claims 18 to 27, wherein R 6 includes at least one heterocyclic ring.

A method or use according to claim 28, wherein the at least one heterocyclic ring is selected from thiophene, große trophischen Geschwüren, furan, oxazole, benzodioxane, benzodioxole, pyrrole, and indole.

A method or use according to any one of claims 18 to 29, wherein R 7 is phenylalkyl. A method or use according to claim 30, wherein R 7 is a große trophischen Geschwüren or unsubstituted benzyl. A method or große trophischen Geschwüren according to claim 31, wherein the benzyl radical with one or more groups selected from halogen, hydroxyl, große trophischen Geschwüren, C alkyl, nitro, cyano, C alkyl and C -Alkylthioether substituted.

A method or use according to any one of claims 18 to 32, wherein Y is O. A method or use according to any one of claims 18 to 34, wherein R 8 is H or a C alkyl radical, große trophischen Geschwüren. A method or use according to any one of the preceding claims, wherein the cell having the phenotype of Ptc loss-function, Hedgehog gain-function or smoothened gain function.

A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 micron or less.

A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 nM große trophischen Geschwüren less, große trophischen Geschwüren.

Use according to any of the preceding claims, wherein the compound is to be große trophischen Geschwüren as part of große trophischen Geschwüren therapeutic or cosmetic application.

Use according to claim 39, wherein the therapeutic or cosmetic application is selected from regulation of neural tissues, bone and cartilage formation and recovery, regulation of spermatogenesis, regulation of smooth muscle, regulation of lung, liver, and other organs, the primitive of the viscera arise, regulation of hematopoietic function and regulation of skin and hair growth.

Use according to claim 39, wherein the therapeutic or cosmetic große trophischen Geschwüren is basal cell carcinoma. Use according to claim 39, wherein the therapeutic or cosmetic application is inhibition of hair growth. Use according to claim 39, wherein the therapeutic or cosmetic application is inhibition of cell growth or proliferation.

Use according to claim 43, wherein the cell growth or cell proliferation is cancer cell growth or proliferation. A method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 mM or less. Arzneimittel, umfassend einen sterilen pharmazeutischen Exzipienten und eine Verbindung dargestellt durch die allgemeine Formel I: A pharmaceutical composition comprising a sterile pharmaceutical excipient and a compound represented by the general formula I: Arzneimittel, umfassend einen sterilen pharmazeutischen Exzipienten und eine Verbindung, dargestellt durch die allgemeine Formel III: A pharmaceutical composition comprising a sterile pharmaceutical excipient and a compound represented by the general formula III: Medicament according to claim 46, wherein E is NR 8.

Medicament according to claim 47, wherein M is absent. A pharmaceutical preparation according to any one of claims 46 to 50, wherein at least one of the große trophischen Geschwüren R 1, R 2 and R 3 includes an aryl group. Drugs one of claims 46 to 51, wherein R 1 represents a branched accordance Alkykest, cycloalkyl or cycloalkylalkyl. A pharmaceutical preparation according to any one of claims 46 to 52, wherein XLR 4 taken together include a cyclic amine.

Drugs one of claims 46 to 53, wherein Y and Z are O according same. A pharmaceutical preparation according to any one of claims 46 to 54, wherein the radical R 1 is bonded to the LO, S or NR 8.

Drugs one of claims 46 to 54, wherein L in each occurrence represents a direct bond according to. Arzneimittel, umfassend einen sterilen pharmazeutischen Exzipienten und eine Verbindung, dargestellt durch die allgemeine Formel VI: A pharmaceutical große trophischen Geschwüren comprising a sterile pharmaceutical excipient and a compound represented by the general formula VI: Medicament according to claim 57, große trophischen Geschwüren, wherein at least one occurrence of J is part of a heterocyclic ring, which große trophischen Geschwüren members.

Medicament according to claim 57, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine. Medicament according to claim 59, wherein the cyclic diamine is a substituted or unsubstituted piperazine. Medicament according to claim 59 or 60, wherein the cyclic diamine with one or Schokolade Körperpackungen mit Krampfadern groups selected from oxo, C alkyl and substituted C alkyl.

Medicament according to claim 57, wherein NJ 2, große trophischen Geschwüren, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N, große trophischen Geschwüren. Medicament according to claim 57, wherein NJR 9, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of Wirksames Mittel von Krampfadern. A pharmaceutical preparation according to any one of claims 57 to 63, wherein one or both occurrences of J with one or more groups selected from C alkyl, C alkyl, C -Alkylthioether, große trophischen Geschwüren, and oxo substituted.

Drugs to any one of claims 57 to 64, wherein R 5 represents a branched alkyl radical according to, cycloalkyl, or cycloalkylalkyl. A pharmaceutical preparation according to any one of claims 57 to 65, große trophischen Geschwüren, wherein R 6 includes at least one heterocyclic ring. Medicament according to claim 66, wherein the at least one heterocyclic ring is selected from thiophene, große trophischen Geschwüren, furan, oxazole, benzodioxane, Benzdioxol, pyrrole, and indole.

Drugs to any one of claims 57 to 67, wherein R 7 represents accordance phenylalkyl. Medicament according to claim 68, wherein R 7 is a substituted or unsubstituted benzyl. Medicament according to claim 69, wherein the benzyl group with one of more groups selected from halogen, hydroxyl, C alkyl, nitro, große trophischen Geschwüren, cyano, C alkyl and C -Alkylthioether substituted.

Drugs one of claims 57 to 70, wherein R 8 is H or a C alkyl accordance. Drugs one of claims 57 to 71, wherein Y is O the große trophischen Geschwüren way. Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Behandlung von Krebs, große trophischen Geschwüren, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel Iist: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula I is: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula III is: Große trophischen Geschwüren einer Verbindung zur Herstellung eines Arzneimittels zur Behandlung von Krebs, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel IVist: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula IV is: Use according to any one of claims 74 to 75, wherein Y and Z represent O, respectively.

Use according Krampfadern in den Beinen offenen Wunden claim 74, wherein E is NR 8. Use according to claim 74, 75 or 78, wherein D represents an aralkyl or Heteroaralkylsubstituiertes amine.

Use according to claim 75 or 76, wherein M is absent: Use according große trophischen Geschwüren any one of claims 74 to 80, große trophischen Geschwüren, wherein X is included in a ring.

Use Service im Innenministerium Varizen to any one of claims 74 to 81, wherein X is included in a diazacarbocycle. Use Massage von Krampfadern in den Beinen zu Hause to any one of claimswherein XLR 4 includes a cyclic amine.

Use according to any one of claims 74 to 83, wherein at least one of the radicals R 1, R 2 and R 3 includes an aryl group. Use according to any one of claims 74 to 84, wherein R 1 represents a branched alkyl, cycloalkyl or cycloalkylalkyl.

Use according to any one of claims 74 to 85, wherein L in each occurrence represents a direct bond. Verwendung einer Verbindung zur Herstellung eines Arzneimittels zur Behandlung von Krebs, wobei die Verbindung ein organisches Molekül, dargestellt durch die allgemeine Formel VIist: Use of a compound for the manufacture of a medicament for the treatment of cancer, wherein the compound is an organic molecule represented by the general formula VI is: Use according to claim 88, wherein at least one occurrence of J is part of a heterocyclic ring, which comprises members.

Use according to claim 88, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine. Use according to claim 90, wherein the cyclic diamine is a substituted or unsubstituted piperazine. Use according to claim 91, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and substituted C alkyl.


Stoffkreislauf - Trophieebenen - Nahrungsbeziehungen einfach erklärt & Beispiel - 1

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